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Cytokine Growth Factor Rev. Low-grade sarcomas, such as a low-grade dedifferentiated liposarcoma with minimal atypia, should be considered, as it has a similar infiltrative growth pattern. This family was later described to have an attentuated FAP syndrome. Epub Aug 8. Epub Jul 6. Germline mutations of APC are associated with FAP, an autosomal dominant condition characterized by thousands of colonic polyps which can progress to colon cancer. Signal transduction pathway analysis in desmoid-type fibromatosis:

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For example, Eccles et al.

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FAP, which is caused by mutations in the adenomatous polyposis coli APC gene on chromosome 5, predispose patients to development of colorectal polyps that often progress to carcinoma. The etiology of DTF is multifactorial, including genetics, hormones, antecedent trauma and other risk factors. Fibromatoses may be classified as superficial or deep type based on location. Rare cells may also be positive for S protein. For instance, given the expression of hormone receptors in DFT, antihormonal therapies tamoxifen, toremifene, raloxifene, progesterone, megestrol, tesolactone have been effective in case reports and small series. The clinical presentation is variable depending on location and extent of the lesion. Epub Oct 2.

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